Tumor microenvironment detection technology based on speckle spectrum contrast OCT

Tumor growth induces changes in tumor microenvironment, including microvessel density, lymphangion density and lymphangiectasia. Therefore, tumor microenvironment detection is great significance in determining tumor types and evaluating tumor development. Based on speckle spectrum contrast optical coherence tomography (SSC-OCT) technique, this study achieved tumor microenvironment detection function. A mouse ear inoculated with H22 liver cancer cells was used to demonstrate the feasibility and efficiency of this method. The experimental results showed that microvessel and lymphangion density increased with H22 liver tumor growth which leaded to lymphangiectasia. Therefore, this method which provide new methods for clinical detection of tumors, can be used to determine tumor type and to evaluate tumor development trend.