Cardiac dysfunction related to cardiac mRNA and protein traffic impairment due to reduced unconventional motor protein myosin-5b expression
MYO5b is the major MYO5 gene expressed in postnatal cardiomyocytes where it transports vesicles, proteins, and multi-protein complexes. Among these are mRNA/RNP complexes affecting electric conductance, sarcomere homeostasis, cell metabolism, and cytoskeletal organization. Impairment in MYO5b expression and function promotes cardiac dysfunction, heart failure, and death.
Authors
- Andreas Pich (ORCID: https://orcid.org/0000-0001-8444-0940)
- Niels Decher (ORCID: https://orcid.org/0000-0002-9433-687X)
- Melanie Ricke‐Hoch (ORCID: https://orcid.org/0000-0001-5479-2275)
- Silke Kauferstein (ORCID: https://orcid.org/0000-0003-0066-8679)
- Tina Jenewein
- Maren Heimerl
- Mirco Müller‐Olling
- Denise Hilfiker‐Kleiner (ORCID: https://orcid.org/0000-0001-6065-9649)
- Sergej Erschow
- Dietmar J. Manstein (ORCID: https://orcid.org/0000-0003-0763-0147)
Institutions
- Goethe University Frankfurt (DE)
- Philipps University of Marburg (DE)
- Medizinische Hochschule Hannover (DE)
- German Centre for Cardiovascular Research (DE)
- University Hospital Frankfurt (DE)
- Phillips University (US)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1093/eurheartj/ehaf047
- Citations
- 2
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- California Department of Fish and Game
- Massachusetts Department of Fish and Game
- Deutsche Forschungsgemeinschaft
- Fondation Leducq
- Stiftung für klinische Forschung zur Förderung der oralen Gesundheit
- Bundesministerium für Umwelt, Naturschutz, nukleare Sicherheit und Verbraucherschutz