Interactions between ADGRF1 (GPR110) and extracellular matrix proteins govern its effects on tumorigenesis in HER2‐positive breast cancer
ADGRF1 switches from a tumour-promoting to tumour-suppressive function upon interaction with laminin-111, leading to improvements in sensitivity to anti-HER2 drugs. Leveraging ADGRF1 interactions with laminin-111 may allow the design of novel therapies against ADGRF1 in HER2+ BC.
Authors
- Martin J. Shea
- Raksha R. Bhat (ORCID: https://orcid.org/0000-0002-0026-1118)
- Suhas Vasaikar (ORCID: https://orcid.org/0000-0001-9763-3899)
- Micah Castillo (ORCID: https://orcid.org/0009-0003-5727-8118)
- Rachel Schiff (ORCID: https://orcid.org/0000-0003-1696-5213)
- Meghana V. Trivedi (ORCID: https://orcid.org/0000-0002-0585-5580)
- Preethi H. Gunaratne (ORCID: https://orcid.org/0000-0002-6487-3463)
- Tahir Hussain (ORCID: https://orcid.org/0000-0002-6353-2317)
- Tasneem Bawa‐Khalfe
- Jamunarani Veeraraghavan (ORCID: https://orcid.org/0000-0002-9524-9487)
- Sarmistha Nanda
- Hee‐Yong Kim (ORCID: https://orcid.org/0000-0002-5546-8052)
- Alexis Ruiz
- Sung Yun Jung (ORCID: https://orcid.org/0000-0003-0985-7206)
- Wangjia Cao (ORCID: https://orcid.org/0009-0007-7249-8492)
- Noor Mazin Abdulkareem (ORCID: https://orcid.org/0000-0003-0189-3069)
- Xinli Liu (ORCID: https://orcid.org/0000-0002-1680-1561)
Institutions
- Baylor College of Medicine (US)
- National Institute on Alcohol Abuse and Alcoholism (US)
- University of Houston (US)
- Seagen (United States) (US)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1111/bph.17463
- Citations
- 6
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- U.S. Department of Defense
- Breast Cancer Research Foundation
- National Institutes of Health