Biomarkers of Radioresistance in Head and Neck Cancer: A New Beginning

The development of biomarkers of radioresistance in head and neck cancer may help personalize treatment. This commentary puts in context the findings of a secondary analysis of NRG/RTOG 9512, a trial of fractionation in T2N0 glottic cancer, which observed that NFE2L2/KEAP1/CUL3 mutations are correlated with local recurrence and disease-free survival. See related article by Guan et al., p. 1615.

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Journal
Clinical Cancer Research
Published
2025-02-18
DOI
https://doi.org/10.1158/1078-0432.ccr-24-4223
Primary Topic
Lung Cancer Research Studies
Type
article
Field-Weighted Citation Impact
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article

Biomarkers of Radioresistance in Head and Neck Cancer: A New Beginning

Yuan James Rao
Clinical Cancer Research
Lung Cancer Research Studies
article

Biomarkers of Radioresistance in Head and Neck Cancer: A New Beginning

Yuan James Rao
article en

Abstract

The development of biomarkers of radioresistance in head and neck cancer may help personalize treatment. This commentary puts in context the findings of a secondary analysis of NRG/RTOG 9512, a trial of fractionation in T2N0 glottic cancer, which observed that NFE2L2/KEAP1/CUL3 mutations are correlated with local recurrence and disease-free survival. See related article by Guan et al., p. 1615.

Clinical Cancer ResearchVol. 31(9)
George Washington University (US)
Good health and well-being
Openalex Percentile: Top 96%
Lung Cancer Research Studies
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Biomarkers of Radioresistance in Head and Neck Cancer: A New Beginning — Yuan James Rao · Clinical Cancer Research (2025) | TGRS Research Map | TGRS