Early cytokine signatures and clinical phenotypes discriminate persistent from resolving MRSA bacteremia
Collectively, this study identifies previously unrecognized cytokine and chemokine signatures that distinguish APMB and ARMB at presentation and in the context of host clinical characteristics associated with increased disease severity. Validation of a biomarker signature that accurately predicts outcomes could guide early therapeutic strategies and interventions to reduce risks of persistent SAB that are associated with worsened morbidity and mortality.
Authors
- Harry Pickering (ORCID: https://orcid.org/0000-0003-2348-5410)
- Maura Rossetti (ORCID: https://orcid.org/0000-0003-3347-6200)
- Michael R. Yeaman (ORCID: https://orcid.org/0000-0002-9468-5252)
- Ying Zheng (ORCID: https://orcid.org/0000-0002-6548-7804)
- Vance G. Fowler (ORCID: https://orcid.org/0000-0002-8048-0897)
- Gemalene Sunga (ORCID: https://orcid.org/0000-0002-8695-1813)
- Elaine F. Reed (ORCID: https://orcid.org/0000-0002-3524-545X)
- Kristina V. Bergersen
- Felix Mba Medie (ORCID: https://orcid.org/0000-0002-8265-4563)
- Felicia Ruffin (ORCID: https://orcid.org/0000-0003-2176-6462)
- Liana C. Chan (ORCID: https://orcid.org/0000-0003-2567-4418)
- Joshua T. Thaden (ORCID: https://orcid.org/0000-0002-3250-0697)
- Rajesh Parmar
- David W. Gjertson
- Alexander Hoffmann
- Batu Sharma
Institutions
- University of California, Los Angeles (US)
- Duke University (US)
- UCLA Medical Center (US)
- Clinical Research Institute (US)
- Harbor–UCLA Medical Center (US)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1186/s12879-025-10620-3
- Citations
- 4
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases