Pan-Cancer Analysis of Oncogenic MET Fusions Reveals Distinct Pathogenomic Subsets with Differential Sensitivity to MET-Targeted Therapy
MET fusions are primary drivers of tumor growth in multiple tumor types - lung cancer and gliomas - and can be effectively targeted with either type I (crizotinib, capmatinib, tepotinib, and savolitinib) or type II (cabozantinib) MET TKIs, with best responses in tumors harboring fusions with partner homodimerization.
Authors
- Morana Vojnic (ORCID: https://orcid.org/0000-0001-5441-4119)
- Stephen Machnicki (ORCID: https://orcid.org/0000-0003-1408-4420)
- Manju Harshan (ORCID: https://orcid.org/0009-0006-0970-4452)
- Tom Zhang (ORCID: https://orcid.org/0009-0007-0979-9719)
- Igor Odintsov (ORCID: https://orcid.org/0000-0001-8073-8803)
- Daniel Lu (ORCID: https://orcid.org/0000-0001-6695-4497)
- Romel Somwar
- Nameeta Shah (ORCID: https://orcid.org/0000-0002-4429-8414)
- William W. Lockwood (ORCID: https://orcid.org/0000-0001-9831-3408)
- Andrea Gazzo (ORCID: https://orcid.org/0009-0009-9282-4667)
- Xiuying Xiao (ORCID: https://orcid.org/0000-0002-9873-0380)
- Zebing Liu
- Monika A. Davare (ORCID: https://orcid.org/0000-0003-1802-7597)
- Marc Ladanyi (ORCID: https://orcid.org/0000-0001-9055-7213)
- Marissa S. Mattar (ORCID: https://orcid.org/0000-0002-2846-9914)
- Qianlan Yao (ORCID: https://orcid.org/0000-0003-0737-4147)
- Alexander Edward Dela Cruz Drilon (ORCID: https://orcid.org/0000-0001-6806-9061)
- Soo‐Ryum Yang (ORCID: https://orcid.org/0000-0002-1051-502X)
- Catherine Z. Beach (ORCID: https://orcid.org/0000-0003-0750-3658)
- Natasha Rekhtman (ORCID: https://orcid.org/0000-0001-5801-3144)
- Ryan Cheng (ORCID: https://orcid.org/0000-0002-7154-5353)
- Afshin Ameri
- Anqi Li (ORCID: https://orcid.org/0000-0003-1409-1858)
- Xiaoyan Zhou (ORCID: https://orcid.org/0000-0001-5999-7237)
- Leo Gili
- Christopher A. Febres‐Aldana
Institutions
- Brigham and Women's Hospital (US)
- BC Cancer Agency (CA)
- Northwell Health (US)
- Memorial Sloan Kettering Cancer Center (US)
- University of British Columbia (CA)
- Oregon Health & Science University (US)
- New York Medical College (US)
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Lenox Hill Hospital (US)
- Stony Brook University Hospital (US)
- Ruijin Hospital (CN)
- Stony Brook School (US)
- Mazumdar Shaw Medical Foundation (IN)
- Fudan University Shanghai Cancer Center (CN)
- North Shore Diabetes and Endocrine Associates (US)
- OHSU Knight Cancer Institute
- Stony Brook University (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-0417
- Citations
- 12
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 15.86