Oxidative and nitrosative stress in bipolar affective disorder and its familial aggregation
The results of the present study advance our knowledge about the role of oxidative and nitrosative stress in BD pathophysiology and its familial aggregation. Additionally, the study demonstrates a direct correlation between the disease severity and levels of ROS/RNS, MPO, total nitrite, and nNOS transcripts in PMNs. However, future research with larger and more diverse participant populations is required to understand these pathways for use as potential biomarkers for a deeper understanding of BD pathophysiology and to improve therapeutic strategies.
Authors
- Sujita Kumar Kar (ORCID: https://orcid.org/0000-0003-1107-3021)
- Madhu Dikshit (ORCID: https://orcid.org/0000-0002-2777-0940)
- Abhishek Kumar Singh (ORCID: https://orcid.org/0000-0002-8703-7820)
- Adarsh Tripathi (ORCID: https://orcid.org/0000-0002-3885-6475)
- PK Dalal (ORCID: https://orcid.org/0000-0001-7317-4480)
- Harpreet Singh (ORCID: https://orcid.org/0000-0001-9507-5248)
Institutions
- Central Drug Research Institute (IN)
- King George's Medical University (IN)
Publication Details
- Journal
- Indian Journal of Psychiatry
- Published
- 2025-02-01
- DOI
- https://doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_396_23
- Citations
- 2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Council of Scientific and Industrial Research, India
- Central Drug Research Institute