An isofagomine analogue with an amidine group in the 1,6-position
The synthesis of an isofagomine analogue with an amidine group in the 1,6-position is described. Density functional theory calculations showed that this compound has a remarkably different charge distribution compared with isofagomine. This may explain why the amidine is a poor glycosidase inhibitor (IC<sub>50</sub> > 50 µM against all tested enzymes) compared with isofagomine.
Authors
- Tereza Cristina Santos Evangelista (ORCID: https://orcid.org/0000-0001-5270-3582)
- Óscar López (ORCID: https://orcid.org/0000-0003-2896-6993)
- Magne O. Sydnes (ORCID: https://orcid.org/0000-0001-9413-6969)
- Idd A. Christensen (ORCID: https://orcid.org/0000-0001-6229-2211)
- Finn L. Aachmann (ORCID: https://orcid.org/0000-0003-1613-4663)
- Monika Moreń
- Emil Lindbäck (ORCID: https://orcid.org/0000-0001-5809-7368)
- Neil Westlund
- I. Caroline Vaaland Holmgard
- Ljupcho Pejov (ORCID: https://orcid.org/0000-0002-0108-3413)
Institutions
- Norwegian University of Science and Technology (NO)
- Institute of Chemistry (CN)
- University of Bergen (NO)
- Arizona State University (US)
- Universidad de Sevilla (ES)
- University of Stavanger (NO)
Publication Details
- Journal
- Royal Society Open Science
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1098/rsos.241877
- Citations
- 2
- Primary Topic
- Carbohydrate Chemistry and Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Universitetet i Stavanger
- Norges Forskningsråd