Cachexia Alters Central Nervous System Morphology and Functionality in Cancer Patients
Our results indicate that cachexia compromises CNS morphology mostly causing changes in the GM of cachectic patients, leading to alterations in regional volume patterns, functional connectivity, neuronal morphology, neuroglia profile and inducing neuroinflammation, all of which may contribute to the loss of homeostasis control and to deficient information processing, as well as to the metabolic and behavioural derangements commonly observed in human cachexia. This first human mapping of CNS cachexia responses will now pave the way to mechanistically interrogate these pathways in terms of their therapeutic potential.
Authors
- Margaret M. Esiri (ORCID: https://orcid.org/0000-0001-6829-0962)
- Marília Seelaender (ORCID: https://orcid.org/0000-0002-9999-8020)
- Leonardo R. Gama (ORCID: https://orcid.org/0000-0002-2633-0935)
- Ricardo Riyoiti Uchida (ORCID: https://orcid.org/0000-0002-4209-8830)
- Gabriele Carmine DeLuca (ORCID: https://orcid.org/0000-0003-0342-5197)
- Joanna D.C.C. Lima (ORCID: https://orcid.org/0000-0001-6804-8666)
- Naomi Antunes da Costa (ORCID: https://orcid.org/0000-0001-9617-1223)
- José Pinhata Otoch (ORCID: https://orcid.org/0000-0002-8293-1508)
- Maria Concepción García Otaduy (ORCID: https://orcid.org/0000-0003-2515-1131)
- Geraldo F. Busatto (ORCID: https://orcid.org/0000-0003-4749-4602)
- Mauricio Berriel Díaz (ORCID: https://orcid.org/0000-0003-4670-919X)
- Mariana Penteado Nucci (ORCID: https://orcid.org/0000-0002-1502-9215)
- Fábio Duran (ORCID: https://orcid.org/0000-0002-7603-6152)
- Estefanía Simoes (ORCID: https://orcid.org/0000-0002-2842-5030)
- Stephan Herzig (ORCID: https://orcid.org/0000-0003-3950-3652)
- Alexandre Carlos Rodrigues Ramos (ORCID: https://orcid.org/0000-0003-2491-4336)
- Fang Chia Bin
- Alessandro Laviano (ORCID: https://orcid.org/0000-0002-9809-3553)
- Paulo Alcantara (ORCID: https://orcid.org/0000-0001-7118-8176)
Institutions
- Universidade de São Paulo (BR)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University of Oxford (GB)
- Irmandade da Santa Casa de Misericórdia de São Paulo (BR)
- Instituto do Câncer do Estado de São Paulo (BR)
- Faculdade de Ciências Médicas da Santa Casa de São Paulo (BR)
- Hospital Universitário da Universidade de São Paulo (BR)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- Technical University of Munich (DE)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/jcsm.13742
- Citations
- 8
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 9.31
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico