Small Arteries From Old Spontaneously Hypertensive Rats Exhibit Enhanced Endothelium‐Independent Vasodilatory Capacity and Reduced Stiffness
In conclusion, resistance arteries from old SHRs are softer and vasodilate more to exogenous nitric oxide than those of WKY rats. This improved endothelial-independent vasodilation is associated with an increased vascular expression of MMP-2 and MMP-9. We further conclude that aging and hypertension effects on the microcirculation may vary between species and vascular beds.
Authors
- Christopher Foote (ORCID: https://orcid.org/0000-0002-8069-2531)
- Francisco I. Ramirez‐Perez (ORCID: https://orcid.org/0000-0003-4920-383X)
- Mariana Morales‐Quinones (ORCID: https://orcid.org/0009-0003-1734-5267)
- Jaume Padilla (ORCID: https://orcid.org/0000-0002-7944-4936)
- Michael A. Hill (ORCID: https://orcid.org/0000-0002-4455-2072)
- Marc A. Augenreich (ORCID: https://orcid.org/0000-0002-0719-8799)
- Jorge A. Castorena‐Gonzalez (ORCID: https://orcid.org/0000-0001-5252-375X)
- Thomas J. Jurrissen
- Luis A. Martinez‐Lemus (ORCID: https://orcid.org/0000-0002-6559-5717)
- Zahra Nourian (ORCID: https://orcid.org/0009-0006-2989-3844)
- Olubodun Michael Lateef (ORCID: https://orcid.org/0000-0002-4207-3422)
- Natnicha Imkaew
- Zhe Sun (ORCID: https://orcid.org/0000-0002-2294-7073)
- Gerald A. Meininger
Institutions
- Tulane University (US)
- Harry S. Truman Memorial Veterans' Hospital (US)
- University of Missouri (US)
Publication Details
- Journal
- Microcirculation
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1111/micc.70004
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health