Keratocan Improves Muscle Wasting in Sarcopenia by Promoting Skeletal Muscle Development and Fast‐Twitch Fibre Synthesis
Keratocan ameliorates muscle atrophy by activating the PI3K/AKT/mTOR pathway, promoting muscle satellite cell proliferation and myogenic differentiation, and facilitating the conversion of slow-to-fast muscle fibres. Our findings demonstrate the potential of keratocan as a novel therapeutic target for osteosarcopenia.
Authors
- Chao Song (ORCID: https://orcid.org/0000-0002-0828-3426)
- Linhai Yang
- Jun Luo (ORCID: https://orcid.org/0000-0001-7120-5618)
- Hanhao Dai (ORCID: https://orcid.org/0000-0002-8197-3183)
- Zhibo Deng
- Yibin Su (ORCID: https://orcid.org/0000-0002-9307-8311)
- Rongsheng Zhang
- Peng Zhang (ORCID: https://orcid.org/0000-0002-6218-1885)
- Yanyan Zhang (ORCID: https://orcid.org/0000-0002-2827-8042)
- Yu Xiu
- Xu Chen (ORCID: https://orcid.org/0000-0002-6463-9933)
- Jie Yu (ORCID: https://orcid.org/0009-0005-5228-3297)
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
- Putian University (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/jcsm.13724
- Citations
- 9
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- National Key Clinical Specialty Discipline Construction Program of China