Metformin-mediated intestinal AMPK activation ameliorates PCOS through gut microbiota modulation and metabolic pathways
This study highlights the therapeutic potential of targeting intestinal AMPK in managing PCOS. By improving both metabolic and reproductive health, activation of AMPK may offer a promising approach for restoring physiological balance in PCOS patients.
Authors
- Qingling Ren (ORCID: https://orcid.org/0000-0002-7383-9873)
- Ruyue Wang (ORCID: https://orcid.org/0000-0003-4821-3331)
- Ning Li (ORCID: https://orcid.org/0009-0001-7242-9805)
- Xiu Li (ORCID: https://orcid.org/0000-0001-6549-5807)
- Yu Si
- Yating Xu
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3389/fendo.2025.1526109
- Citations
- 7
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province