Body weight in systemic lupus erythematosus is associated with disease activity and the adaptive immune system, independent of type I IFN
We characterized the clinical, immunological and transcriptomic profiles of SLE patients with varying BMI. As low BMI was identified as an independent parameter for explaining disease activity, cachexia is considered one of the systemic symptoms of active SLE. Additionally, BMI influenced the phenotypic and transcriptomic alterations of acquired immune cells, independent of IFN signaling. These findings provide insights into the pathogenesis of SLE.
Authors
- Hirofumi Shoda (ORCID: https://orcid.org/0000-0002-1536-0303)
- Tomohisa Okamura (ORCID: https://orcid.org/0000-0001-7257-5557)
- Takahiro Itamiya (ORCID: https://orcid.org/0000-0002-1020-0108)
- Keishi Fujio (ORCID: https://orcid.org/0000-0001-7276-5254)
- Yumi Tsuchida (ORCID: https://orcid.org/0000-0003-3236-6157)
- Hiroyuki Teruya
Institutions
- Tokyo Medical University Hospital (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1503559
- Citations
- 6
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 10.01
Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare
- University of Tokyo
- Chugai Pharmaceutical
- Japan Society for the Promotion of Science