In vitro Anticancer Activity of Curcuma caesia on Human Skin Cancer Cell Line SK-MEL-28 (Skin Melanoma)

Background: The hydroalcoholic extract derived from Curcuma caesia (CCHE) is recognized for its traditional use and well-established medicinal properties, often prescribed for the treatment of various ailments like skin cancer. Global trends favoring the utilization of non-toxic plant-based products, particularly those aligned with conventional medicinal practices and considering the reliance of developing countries on herbal remedies for primary healthcare. Methods: This study aims to investigate the in-vitro cytotoxic effects of CCHE on the SK-MEL-28 human skin cancer cell line (specifically, skin melanoma) through MTT assays. The evaluation revealed that the hydroalcoholic extract of CCHE exhibited a notable inhibitory effect on the SK-MEL-28 cell line, with a percentage inhibition of 80.29% observed at lower concentrations (25 g/ml) and reaching 92.65% at higher concentrations (400 g/ml). Result: These findings suggest that CCHE, herein referred to as CCHE (Potentiated Hydroalcoholic Extract), instigated a mechanism leading to cell arrest, thereby impeding the proliferation of cancer cells. In comparison to conventional medicines, the observed inhibitory effect of CCHE underscores its potential as a cytotoxic agent against human skin cancer cells.