Review on quantitative determination of preservatives - methyl paraben and propyl paraben by thin layer chromatography

In the field of analytical chemistry and various pharmaceutical fields the separation techniques are widely used to study specific compounds from a mixture or a complex material. One such separation technique is called Chromatography. A simple, rapid, and cost-effective TLC method was developed and validated for the quantitative determination of methyl paraben and propyl paraben in pharmaceutical and cosmetic products. The method employed a mobile phase consisting of ethyl acetate-methanol-water (80:10:10, v/v/v) and showed good linearity (R2 > 0.99), accuracy (recovery 95-105%), precision (RSD < 2%), and specificity. The limits of detection and quantitation were 0.1 μg and 0.5 μg, respectively. This TLC method can be used for quality control and regulatory purposes. Shashank Tiwari1and Shreya Talreja2. Thin Layer Chromatography (TLC) VS. Paper Chromatography: A Review. Acta Scientific Pharmaceutical Sciences (ISSN: 2581-5423). 2022;6(9): 05- 09. Sanjeet Kumar1, K. 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