Causal inference study of plasma proteins and blood metabolites mediating the effect of obesity-related indicators on osteoporosis
Obesity may confer a protective effect against osteoporosis, potentially mediated by EHMT2 in plasma proteins and alanine in blood metabolites. Further empirical research is required to fully elucidate the mechanisms behind the influence of obesity on osteoporosis. Interventions on obesity-related factors to reduce the risk of osteoporosis while controlling other adverse effects associated with obesity may require further research.
Authors
- Jianxiong Wang (ORCID: https://orcid.org/0000-0002-6861-7483)
- Fu‐Hua Sun (ORCID: https://orcid.org/0000-0002-8808-7838)
- Yue Yang (ORCID: https://orcid.org/0000-0002-1481-8175)
- Maomao Huang
- Fei Xing (ORCID: https://orcid.org/0000-0002-2372-3629)
- Qi Deng (ORCID: https://orcid.org/0000-0001-5619-7920)
- Rui Shi (ORCID: https://orcid.org/0000-0001-6769-5650)
- Chi Zhang (ORCID: https://orcid.org/0000-0002-6217-6509)
- Dan Li (ORCID: https://orcid.org/0000-0001-6765-6627)
- Lei Li (ORCID: https://orcid.org/0000-0002-1867-106X)
- Fangyuan Xu (ORCID: https://orcid.org/0009-0002-2815-8961)
- Yue Hu (ORCID: https://orcid.org/0000-0002-9240-6483)
- Jiayi Zhu (ORCID: https://orcid.org/0009-0003-0463-9442)
- Zhangyu Xv
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3389/fendo.2025.1435295
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Southwest Medical University
- Medical Research Council