CAMTA1-immunonegative epithelioid hemangioendotheliomas of the liver: a clinicopathological and molecular analysis of seven cases

Our study reported 7 CAMTA1-immunonegative hepatic EHEs and most of them were <i>TFE3</i>-rearranged EHEs with morphology variation. Moreover, there does exist the CAMTA1-immunonegative but <i>CAMTA1</i>-rearranged EHE cases. Therefore, the diagnosis of EHE should be based on morphology, combined with CAMTA1 and TFE3 IHC, and if necessary, supplemented by genetic analysis including FISH and NGS, to establish correct diagnosis.