Known laboratory abnormalities and potential targets for the conservative treatment of avascular osteonecrosis
Avascular osteonecrosis (AON) is a common condition that most often affects people of working age (20–60 years). The disease leads to rapid destruction and collapse of the subchondral bone with subsequent development of secondary osteoarthritis of the affected joint. The current data on laboratory abnormalities in AON are presented. Biomarkers directly related to the development and progression of AON are described in detail. Ideas for future research are formulated to improve the detection and treatment of the disease.
Authors
- А. М. Лила (ORCID: https://orcid.org/0000-0002-6068-3080)
- D. V. Kapitonov (ORCID: https://orcid.org/0000-0002-0454-0974)
- V. Bialik (ORCID: https://orcid.org/0000-0002-3745-0924)
- V. А. Nesterenko (ORCID: https://orcid.org/0000-0002-7179-8174)
- A. A. Chernikova (ORCID: https://orcid.org/0000-0002-5256-7346)
- С. А. Макаров (ORCID: https://orcid.org/0000-0001-8563-0631)
- М. А. Макаров (ORCID: https://orcid.org/0000-0002-5626-7404)
- E. I. Byalik (ORCID: https://orcid.org/0000-0001-7938-1536)
- Andrey E. Karateev (ORCID: https://orcid.org/0000-0002-1391-0711)
- A. I. Gorelova (ORCID: https://orcid.org/0009-0009-5068-3536)
Institutions
- Ministry of Health of the Russian Federation (RU)
- Association of Rheumatologists of Russia (RU)
Publication Details
- Journal
- Modern Rheumatology Journal
- Published
- 2025-02-15
- DOI
- https://doi.org/10.14412/1996-7012-2025-1-83-90
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00