Brigatinib can inhibit proliferation and induce apoptosis of human immortalized keratinocyte cells
This study confirms the inhibition of HaCaT cells growth and progression by brigatinib and highlights the potential value of the PI3K/AKT pathway as a therapeutic target for brigatinib-induced dermal toxicities.
Authors
- Dan Zhao (ORCID: https://orcid.org/0000-0001-7066-9058)
- Linjie Ju
- Peng Cao (ORCID: https://orcid.org/0000-0002-2809-506X)
- Zhixian Liu (ORCID: https://orcid.org/0000-0003-4710-1442)
- Ji‐Fu Wei (ORCID: https://orcid.org/0000-0001-6412-3251)
- Qi Yang (ORCID: https://orcid.org/0000-0003-1899-0586)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiangsu Cancer Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3389/fphar.2025.1524277
- Citations
- 3
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 4.88
Funders
- China International Medical Foundation
- Jiangsu Cancer Hospital