Monotropein inhibits epithelial–mesenchymal transition in chronic colitis via the mTOR/P70S6K pathway
The study indicates that monotropein inhibits the development of EMT in DSS-induced chronic colitis mice and TGF-β1-induced IEC-6 cells. Its inhibitory effect on EMT is associated with the mTOR/P70S6K pathway.
Authors
- Shaozhen Hou (ORCID: https://orcid.org/0000-0002-1233-2809)
- Shaowen Zhong (ORCID: https://orcid.org/0000-0002-8671-894X)
- Jie Gao (ORCID: https://orcid.org/0000-0002-3366-3156)
- Yonger Chen
- Jian Liang (ORCID: https://orcid.org/0000-0002-6027-0278)
- Haiyang Huang (ORCID: https://orcid.org/0000-0002-5264-8349)
- Yuxuan Chen (ORCID: https://orcid.org/0000-0003-3819-5010)
- Ying Chen (ORCID: https://orcid.org/0000-0001-6396-7815)
- Yuan Jin (ORCID: https://orcid.org/0000-0002-7968-450X)
- Jiaying Liu (ORCID: https://orcid.org/0000-0002-1274-3800)
- Tao Zhang (ORCID: https://orcid.org/0000-0003-2765-2802)
- Jing Zhang (ORCID: https://orcid.org/0009-0004-9226-6523)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- University of the Visayas (PH)
- Guangzhou Vocational College of Science and Technology (CN)
- Puer University (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3389/fphar.2025.1536091
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00