Dezocine modulates the reinstatement of conditioned place preference in morphine-dependent rats via the dopamine reward circuitry
These findings suggest that dezocine may exert its therapeutic effects by inhibiting kappa opioid receptor activation and enhancing dopamine signaling in reward-related brain circuitry. The increase in p-DARPP32 expression in key brain regions supports this mechanism, providing insights into the potential clinical application of dezocine for managing opioid addiction. Dezocine represents a promising candidate for opioid addiction treatment, with the ability to control withdrawal symptoms and prevent relapse.
Authors
- Weifeng Yu (ORCID: https://orcid.org/0000-0003-1979-6304)
- Yi Jia (ORCID: https://orcid.org/0000-0002-4563-917X)
- Xiaoqiang Wang (ORCID: https://orcid.org/0000-0002-1892-5613)
- Yan He (ORCID: https://orcid.org/0000-0003-1839-6894)
- Feixiang Wu
- Zhaoyan Piao (ORCID: https://orcid.org/0000-0003-3866-0840)
- Hui‐Qiu Wu
Institutions
- Fujian Medical University (CN)
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Wenzhou Medical University (CN)
- Renji Hospital (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3389/fnins.2025.1507747
- Citations
- 1
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Natural Science Foundation of China