Roxadustat regulates the cell cycle and inhibits proliferation of mesangial cells via the hypoxia-inducible factor-1α/P53/P21 pathway
Roxadustat regulates and inhibits cell proliferation of MCs via the HIF-1α/p53/p21 pathway. This may be a potential therapeutic target in the early stages of diabetic kidney disease.
Authors
- Baijie Feng
- Xiuhong Yang (ORCID: https://orcid.org/0000-0002-7463-8926)
- Qingmei Yang (ORCID: https://orcid.org/0000-0003-2129-045X)
- Huimin Jin (ORCID: https://orcid.org/0000-0001-9290-1401)
- Yun Cheng (ORCID: https://orcid.org/0000-0001-6497-4590)
Institutions
- Fudan University (CN)
- Huadong Hospital (CN)
- Shanghai Public Health Clinical Center (CN)
- Pudong Medical Center (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3389/fcell.2025.1503477
- Citations
- 5
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- Fudan University