Altered white matter microstructural integrity in patients with postherpetic neuralgia: a combined DTI and DTI-NODDI study
Our study highlights significant microstructural changes in white matter tracts in patients with PHN, indicating compromised neural integrity that correlates with increased pain perception and emotional distress. NODDI demonstrated superior sensitivity in detecting these alterations compared to traditional DTI metrics, underscoring its potential for enhancing diagnostic and therapeutic approaches in managing chronic pain conditions like PHN.
Authors
- Min Yan (ORCID: https://orcid.org/0000-0002-1355-1261)
- Risheng Yu
- Ying Wu (ORCID: https://orcid.org/0000-0001-5959-9466)
- Xiaopei Xu (ORCID: https://orcid.org/0000-0002-0342-383X)
- Chao Wang (ORCID: https://orcid.org/0000-0002-5268-9570)
- Lina Yu (ORCID: https://orcid.org/0000-0003-1342-2969)
- Wei Qian (ORCID: https://orcid.org/0000-0002-2970-5069)
Institutions
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3389/fnins.2025.1552961
- Citations
- 1
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- National Natural Science Foundation of China
- Science and Technology Program of Zhejiang Province