Mechanism of PAVA-induced toxicity and inflammation in a cocultured skin cell model
100 μM PAVA elicits pronounced cytotoxic, oxidative, and pro-inflammatory effects on cocultured skin cell model, particularly at higher concentrations and prolonged exposure durations. These findings underscore the necessity of exercising caution when employing PAVA for therapeutic purposes and highlight the imperative for further research to mitigate its adverse consequences as a riot control agent.
Authors
- Yifeng Yin (ORCID: https://orcid.org/0000-0002-2739-6477)
- Zhen Wang (ORCID: https://orcid.org/0000-0002-7644-9547)
- Yanli Liu (ORCID: https://orcid.org/0000-0003-0886-8907)
- Fanghui Wu
- Tianqi Zhou
- Wenjie Cheng
- Danning Xu (ORCID: https://orcid.org/0000-0003-2958-1825)
- Yun‐Yang Song
Institutions
- Shanghai Ocean University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3389/fphar.2025.1531459
- Primary Topic
- Advancements in Transdermal Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00