Potential activity of Ferula macrecolea essential oil for treating Giardia lamblia infection through modulating electrolytes and suppressing NF-κB p65 pathway
This study's results demonstrate the extract's efficacy <i>in vitro</i> against <i>G. lamblia</i>, exhibiting minimal cytotoxicity towards normal cells. Furthermore, the extract was shown to manage giardiasis in murine models by modulating electrolyte levels and inflammatory responses via suppressing the NF-κB p65/TLR pathways. However, further research is necessary to clarify the specific efficacy and mechanisms of action of the extract in combating <i>G. lamblia</i> infection.
Authors
- Javad Ghasemian Yadegari (ORCID: https://orcid.org/0000-0002-3897-2222)
- Sajad Yaghoubi (ORCID: https://orcid.org/0000-0002-4729-147X)
- Leila Masoori (ORCID: https://orcid.org/0000-0002-8852-1075)
- Hossein Mahmoudvand (ORCID: https://orcid.org/0000-0003-4194-393X)
- Iraj Salimikia (ORCID: https://orcid.org/0000-0001-9268-7089)
- Amal Khudair Khalaf (ORCID: https://orcid.org/0000-0002-5712-7868)
Institutions
- Thi Qar University (IQ)
- Lorestan University of Medical Sciences (IR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3389/fphar.2025.1542425
- Citations
- 3
- Primary Topic
- Parasitic Infections and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 6.14
Funders
- Lorestan University of Medical Sciences