High-dose radiation induces dendritic cells maturation by promoting immunogenic cell death in nasopharyngeal carcinoma
High-dose radiation-induced apoptosis of NPC 5-8F cells is a form of ICD, which plays an important role in regulating DC immune function. These findings provide insight into the immunomodulatory effects of radiotherapy in NPC and its potential to enhance tumor immunotherapy through DC activation.
Authors
- Jin Chen (ORCID: https://orcid.org/0000-0002-5557-2079)
- Zhu Zeng (ORCID: https://orcid.org/0000-0003-1989-5142)
- Xianlin Zeng (ORCID: https://orcid.org/0000-0002-7600-605X)
- Lijing Teng (ORCID: https://orcid.org/0000-0003-0219-3689)
- Zhou Shi (ORCID: https://orcid.org/0000-0001-5010-9459)
- Shuai Zhang (ORCID: https://orcid.org/0000-0003-3646-1522)
- Yun Wang (ORCID: https://orcid.org/0000-0001-8619-0455)
- Xin Jin
- Zuquan Hu (ORCID: https://orcid.org/0000-0003-4978-4363)
- Shichao Zhang (ORCID: https://orcid.org/0000-0002-3797-4103)
- Jinhua Long (ORCID: https://orcid.org/0000-0003-0325-4340)
- Junhong Leng (ORCID: https://orcid.org/0000-0002-8450-6329)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1554018
- Citations
- 7
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- National Natural Science Foundation of China
- Science and Technology Program of Guizhou Province