Multiomics insights into BMI-related intratumoral microbiota in gastric cancer
In conclusion, LBMI is an independent risk factor for poor prognosis in gastric cancer patients and may have an inhibitory effect on postoperative adjuvant chemotherapy. Intratumor flora of gastric cancer patients with different BMI levels differed, with different immune cell infiltration and metabolic characteristics. The genus Abiotrophia may promote gastric cancer development and progression by regulating eosinophils and the purine metabolism pathway, which provides a new idea for the precise treatment of gastric cancer.
Authors
- Zhengchen Jiang (ORCID: https://orcid.org/0000-0003-4765-8830)
- Ruihong Xia
- Zhuo Liu (ORCID: https://orcid.org/0000-0002-1137-7220)
- Kang Liu (ORCID: https://orcid.org/0000-0002-7109-3174)
- Shi Wang (ORCID: https://orcid.org/0000-0002-9571-9864)
- Yuan Li (ORCID: https://orcid.org/0000-0002-6245-9437)
- Chuhong Pang
- Yingsong Zheng (ORCID: https://orcid.org/0000-0002-2984-7884)
- Yubo Ma (ORCID: https://orcid.org/0000-0002-5506-1607)
- Xiangdong Cheng
- Kailai Yin
- Bo Zhang (ORCID: https://orcid.org/0009-0002-9957-5914)
Institutions
- Zhejiang Chinese Medical University (CN)
- Chinese Academy of Sciences (CN)
- Wenzhou Medical University (CN)
- Zhejiang Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3389/fcimb.2025.1511900
- Citations
- 2
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Medical Science and Technology Project of Zhejiang Province
- Natural Science Foundation of Zhejiang Province
- Science and Technology Program of Zhejiang Province