Claudin-2 enhances human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells by modulating antibody binding and complement activation
Our findings indicate that Claudin-2 enhances the cytotoxicity of porcine ECs through modulating antibody binding and complement activation. The deficient of Claudin-2 in genetically modified pigs is likely to protect porcine ECs and enhance xenograft survival in pig-to-human organ or tissue xenotransplantation.
Authors
- Jinmei Wu (ORCID: https://orcid.org/0000-0002-2947-9540)
- Yang Cao (ORCID: https://orcid.org/0000-0002-0058-614X)
- Zixi Chen (ORCID: https://orcid.org/0000-0001-6350-2997)
- Hanchao Gao (ORCID: https://orcid.org/0000-0002-3225-801X)
- Fang Yang (ORCID: https://orcid.org/0000-0001-6922-6348)
- Zhuoheng Song
- Yanmei Li (ORCID: https://orcid.org/0000-0003-1215-5010)
- Yan Yu (ORCID: https://orcid.org/0009-0004-3004-3770)
- Weilong Li (ORCID: https://orcid.org/0000-0002-7913-5260)
- Ting Xie (ORCID: https://orcid.org/0000-0002-0243-3112)
- Liying Zhou (ORCID: https://orcid.org/0000-0002-0620-6216)
- Dexin Yang (ORCID: https://orcid.org/0000-0001-5658-2351)
- Peishan Chen (ORCID: https://orcid.org/0000-0002-6968-4303)
- Zigan Xu
- Shaodong Luan
Institutions
- Longgang Central Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1547512
- Citations
- 1
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.84