Focused ultrasound–induced blood–brain barrier opening: A comparative analysis of permeability quantification based on Ktrans and PS
Both <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:semantics> <mml:mrow> <mml:msup><mml:mrow><mml:mi>K</mml:mi></mml:mrow> <mml:mrow><mml:mtext>trans</mml:mtext></mml:mrow> </mml:msup> </mml:mrow> <mml:annotation>$$ {K}^{\mathrm{trans}} $$</mml:annotation></mml:semantics> </mml:math> and PS seem to be eligible options for the quantification of BBB opening, and the correct choice depends on the specifics of the acquired DCE-MRI data. Additionally, spatial regularization has demonstrated its importance in enhancing the accuracy and reproducibility of results for both models.
Authors
- Jiří Vitouš (ORCID: https://orcid.org/0000-0002-9183-8794)
- Eva Dražanová (ORCID: https://orcid.org/0000-0003-1844-4489)
- Radovan Jiřík (ORCID: https://orcid.org/0000-0003-2555-9428)
- Lucie Krátká (ORCID: https://orcid.org/0000-0003-1104-5215)
- Ondřej Macíček (ORCID: https://orcid.org/0000-0002-0179-5779)
- Zenon Starčuk (ORCID: https://orcid.org/0000-0002-1218-0585)
- Denisa Hývlová (ORCID: https://orcid.org/0009-0000-7899-8470)
Institutions
- Masaryk University (CZ)
- Czech Academy of Sciences, Institute of Scientific Instruments (CZ)
- Brno University of Technology (CZ)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1002/mrm.30446
- Citations
- 2
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Ministerstvo Školství, Mládeže a Tělovýchovy
- Grantová Agentura České Republiky