Multicomponent One-Pot Synthesis of Imidazo[1,2-a]pyridine Functionalized with Azides

Imidazo[1,pyridines (IMPs) are valuable heterocycles, present in bioactive compounds and drugs.Analogs that incorporate azide moieties are useful intermediates in organic synthesis and can be used as synthetic platforms to access more complex products.Isocyanide-based multicomponent reactions such as Groebke-Blackburn-Bienaym (GBB-3CR) are versatile tools to synthesized IMPs, in which orthogonal reagents are included into components to increase its synthetic potential.Herein we developed a one-pot process to access IMPs functionalized with azides under mild conditions, which are synthetic platforms for further post-transformations.