Radiation Retinopathy: Microangiopathy-Inflammation-Neurodegeneration
Although the gross anatomy of the retina does not seem to be affected by proton beam irradiation, the cellular composition and retinal function changed significantly in both WT and Cx3cr1 mice reflecting the clinical situation. Moreover, cataract formation was one of the major long-term effects of irradiation. We conclude that the murine model (WT and Cx3cr1 genotype) can be used to investigate proton-beam associated side effects in vivo as well as to test prospective interventions. Moreover, the loss of Cx3cr1 seems to be partially protective.
Authors
- Nadine Reichhart
- Inga-Marie Pompös (ORCID: https://orcid.org/0000-0001-9314-8378)
- Susanne A. Wolf (ORCID: https://orcid.org/0000-0003-0922-8418)
- Jens Heufelder (ORCID: https://orcid.org/0000-0002-1782-7376)
- Norbert Kociok (ORCID: https://orcid.org/0000-0003-4898-6035)
- Anja‐Maria Davids (ORCID: https://orcid.org/0000-0003-0904-8177)
- Sergej Skosyrski
- Antonia Maria Joussen
Institutions
- Max Delbrück Center (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Cells
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3390/cells14040298
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84