Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated With Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children With Severe Malaria

Acute kidney injury (AKI) is common and predicts mortality in severe malaria. Studies have reported an increased incidence of AKI in males with hemolytic features of severe malaria. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked enzymopathy, can induce hemolysis. We evaluated whether the G6PD African allele (A-) was associated with AKI in children with severe malaria. The prevalence of G6PD deficiency was 16.7% among hemizygous male children and 2.4% in female children. G6PD deficiency was associated with 2.56-fold odds of AKI (95% confidence interval, 1.33-4.93; P = .005), adjusting for age, sex, site, nutritional status, and features of hemolysis.

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Publication Details

Journal
The Journal of Infectious Diseases
Published
2025-02-12
DOI
https://doi.org/10.1093/infdis/jiaf080
Primary Topic
Malaria Research and Control
Type
article
Field-Weighted Citation Impact
0.00

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article

Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated With Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children With Severe Malaria

Andrea L. Conroy, Claire Liepmann, Olivia J. Bednarski, Chandy C. John et al.
The Journal of Infectious Diseases
Malaria Research and Control
article

Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated With Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children With Severe Malaria

Andrea L. Conroy, Claire Liepmann, Olivia J. Bednarski, Chandy C. John, Ruth Namazzi, Tae-Hwi Linus Schwantes-An, Robert Opika Opoka, Anthony Batte, Giselle Lima-Cooper, Caroline Kazinga, Marco Abreu, Michael Goings
article en

Abstract

Acute kidney injury (AKI) is common and predicts mortality in severe malaria. Studies have reported an increased incidence of AKI in males with hemolytic features of severe malaria. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked enzymopathy, can induce hemolysis. We evaluated whether the G6PD African allele (A-) was associated with AKI in children with severe malaria. The prevalence of G6PD deficiency was 16.7% among hemizygous male children and 2.4% in female children. G6PD deficiency was associated with 2.56-fold odds of AKI (95% confidence interval, 1.33-4.93; P = .005), adjusting for age, sex, site, nutritional status, and features of hemolysis.

The Journal of Infectious DiseasesVol. 232(1)
Indiana University Health (US), Aga Khan University Nairobi (KE), World Health Organization - Uganda (UG), Center for Global Health (US), Aga Khan University (TZ), Indiana University School of Medicine, Indiana University – Purdue University Indianapolis (US), Makerere University (UG)
Norges Idrettshøgskole, National Institute of Allergy and Infectious Diseases, Fogarty International Center, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences
Good health and well-being
Openalex Percentile: Top 96%
Malaria Research and Control
DOIOpen Access PDFOpenAlex
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