Analysis of the inflammatory storm response and heparin binding protein levels for the diagnosis and prognosis of sepsis-associated encephalopathy

The occurrence of SAE is closely correlated with age, concomitant diabetes, SOFA score, APACHE II score, serum cytosolic inflammatory cytokine levels (IL-2/6/10, TNF-α, and IFN-γ), HBP, and serum cholinesterase levels. In addition, inflammatory storms are associated with the mechanism of SAE, and high expression levels of the inflammatory cytokines IL-6 > 5000 pg/ml, IL-10 > 1000 pg/ml, and HBP > 300 ng/ml in patients with sepsis contribute to the early diagnosis of SAE. In addition, IL-6 > 5000 pg/ml was also associated with an increase in 28-day mortality (P < 0.05), suggesting that the level of inflammatory storms may be related to the mechanism of sepsis-related SAE and 28-day mortality. According to the LASSO results, when SAE patients admitted to the intensive care unit satisfy HBP > 300 ng/ml, IL6 > 5000 pg/ml, decreased GCS score, and increased APACHEII score, it suggests that the patient's 28-day mortality rate is higher, and it also validates that inflammatory storm can be used as a predictor of prognosis for SAE patients.