Interpretation of inhomogeneous magnetization transfer in myelin water using a four‐pool model with dipolar reservoirs

The drop in <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:semantics> <mml:mrow> <mml:msub><mml:mrow><mml:mi>T</mml:mi></mml:mrow> <mml:mrow><mml:mn>1</mml:mn> <mml:mi>D</mml:mi></mml:mrow> </mml:msub> <mml:mo>(</mml:mo> <mml:mtext>myelin</mml:mtext> <mml:mo>)</mml:mo></mml:mrow> <mml:annotation>$$ {T}_{1D}\left(\mathrm{myelin}\right) $$</mml:annotation></mml:semantics> </mml:math> in the three-week post-injury cords suggests that <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:semantics> <mml:mrow> <mml:msub><mml:mrow><mml:mi>T</mml:mi></mml:mrow> <mml:mrow><mml:mn>1</mml:mn> <mml:mi>D</mml:mi></mml:mrow> </mml:msub> <mml:mo>(</mml:mo> <mml:mtext>myelin</mml:mtext> <mml:mo>)</mml:mo></mml:mrow> <mml:annotation>$$ {T}_{1D}\left(\mathrm{myelin}\right) $$</mml:annotation></mml:semantics> </mml:math> could potentially distinguish between functional myelin and myelin debris; however, more studies are needed to confirm this.