Metabolically-oriented effect of fucoidan from Sargassum feldmannii brown algae on the mda-mb-231 human breast cancer cells

Objective. To study the effect of fucoidan from brown algae S. feldmannii (SfF2) on the metabolism of MDA-MB-231 breast cancer cells. Materials and methods. The bioenergetic potential of MDA-MB-231 cells was assessed under the influence of various factors (insulin, epidermal growth factor, phorbol ester, and X-rays) stimulating tumor progression. The metabolically oriented effect of fucoidan SfF2 (200 µg/ml) on the colony formation process of MDA-MB-231 human breast cancer cells was determined using the soft agar method under normal conditions and under the influence of various carcinogenic factors. Results. Fucoidan from brown algae S. feldmannii was found to reduce the number of colonies of MDA-MB-231 cells induced by insulin, epidermal growth factor (EGF), and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) by more than 50 % compared to control cells. Conclusion. The use of fucoidan as an adjunct to standard therapy appears to be a promising strategy for enhancing the efficacy of anticancer treatment.