Pain Pressure Threshold as a Non-Linear Marker of Neural Adaptation in Amputees: Evidence from the DEFINE Cohort
Our findings indicate that sex, age, BMI, and time since amputation are significant factors influencing PPT in amputees, with nonlinear relationships observed for age, BMI, and amputation duration. These results suggest that physiological and disease-related factors (such as age, BMI, and duration of injury) have specific peaks for optimal PPT, highlighting their role in the brain's compensatory system and potential implications for targeted pain management strategies.
Authors
- Linamara Rizzo Battistella (ORCID: https://orcid.org/0000-0001-5275-0733)
- Felipe Fregni (ORCID: https://orcid.org/0000-0002-1703-7526)
- Marta Imamura (ORCID: https://orcid.org/0000-0003-0355-9697)
- Anna Carolyna Gianlorenço (ORCID: https://orcid.org/0000-0002-7334-3835)
- Guilherme J. M. Lacerda
Institutions
- Harvard University (US)
- Universidade Federal de São Carlos (BR)
- Spaulding Rehabilitation Hospital (US)
- Massachusetts General Hospital (US)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Publication Details
- Journal
- NeuroSci
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3390/neurosci6010017
- Citations
- 2
- Primary Topic
- Musculoskeletal pain and rehabilitation
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo