Targeting the NLRP3 in macrophages contributes to senescence cell clearance in radiation-induced skin injury
This study underscored NLRP3 in macrophages as a critical intervention target for senescence cell immunosurveillance and emphasized Nr-CWS as a potential therapeutic agent for accelerating senescence cell clearance in RISI.
Authors
- Wanchao Chen (ORCID: https://orcid.org/0000-0002-2490-8860)
- Shijie Dai (ORCID: https://orcid.org/0000-0001-8315-9073)
- Fulong Wang (ORCID: https://orcid.org/0000-0002-7083-9675)
- Gaoyu Liu (ORCID: https://orcid.org/0000-0003-4652-8583)
- Gang Wu (ORCID: https://orcid.org/0000-0002-4764-8272)
- Chunmeng Shi (ORCID: https://orcid.org/0000-0002-8264-738X)
- Yan Chen (ORCID: https://orcid.org/0009-0004-6856-263X)
- Peng Luo (ORCID: https://orcid.org/0000-0002-9668-4771)
- Lingling Wu (ORCID: https://orcid.org/0000-0002-7166-3966)
Institutions
- Army Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1186/s12967-025-06204-z
- Citations
- 4
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.22