Experimental study of the pharmacological activity of the developed solid soap for the treatment of psoriasis

Given the relevance of creating new products in the form of solid soaps from natural ingredients for the treatment of psoriasis, we chose this area for our own research. Based on the results of preliminary studies, we developed the composition and technology of solid soaps based on palm kernel, coconut, avocado, almond, olive, castor oils with the addition of pomegranate seed oil, as well as citric and salicylic or lactobionic acids. The next step is to study the pharmacological activity, which will confirm or refute the feasibility of using the developed soaps for the treatment (in complex therapy) and/or prevention of psoriasis exacerbations. The aim was to study the pharmacological activity of solid soap for use in the complex therapy of psoriasis. The psoriasis model was reproduced by applying 5% Imiquimod cream to the propylated back of animals (white rats aged 3–4 months). The intensity of inflammation, as well as the activity of the test samples, was assessed by the thickness of the skin fold (mm). The degree of skin lesion intensity was assessed in points from 0 to 4. On the 11th day of the experiment, the animals were administered the tested samples of solid soap at a dose of 25 mg/kg. The treatment period lasted 5 days. The application of the studied samples reduced the manifestations of local skin inflammation in rats with model psoriasis. A gradual decrease in both edema of adjacent tissues and the intensity of skin inflammation was observed, which was more pronounced when using the sample containing citric and salicylic acids (skin fold thickness 3.4 ± 0.1 mm (initial data 4.0 ± 0.1 mm), inflammation intensity 0 points (initial data 4.0 points). On the model of skin inflammation in rats caused by the application of 5% Imiquimod cream, it was found that the sample, which contains salicylic and citric acids as active pharmaceutical ingredients, has an advantage in pharmacological activity compared to other samples under study. It was found that the sample containing salicylic and citric acids as active pharmaceutical ingredients has an advantage in pharmacological activity compared to other samples (skin fold thickness 3.4 mm (initial data 4.0 mm), inflammation intensity 0 points (initial data 4.0 points).