The influence of amniotic membrane proteins on corneal regeneration when delivered directly or using hydrogel platforms
Applying new biocompatible hydrogels to the ocular surface that release AM proteins may help close corneal wounds caused by caustic burns. The aggressive nature of burns hinders the detection of differences in the wound area between treatments 28 days after injury. However, improving the adhesion of a solid hydrogel to the mucosa of the ocular surface could enhance these outcomes by keeping the implant in contact with the wound for a longer period.
Authors
- Javier Mendicute (ORCID: https://orcid.org/0000-0002-8603-6623)
- Arantxa Acera (ORCID: https://orcid.org/0000-0002-6942-6144)
- Jorge Burgos (ORCID: https://orcid.org/0000-0002-9923-9403)
- Ana Aiastui (ORCID: https://orcid.org/0000-0001-5561-6564)
- Félix Elortza (ORCID: https://orcid.org/0000-0001-8839-5438)
- Elena Vecino (ORCID: https://orcid.org/0000-0002-1672-5132)
- David Esporrín‐Ubieto (ORCID: https://orcid.org/0000-0002-9858-415X)
- Itxaso Calafel (ORCID: https://orcid.org/0000-0003-1033-3522)
- Mercedes Fernández (ORCID: https://orcid.org/0000-0002-7322-8001)
- Ana S. Sonzogni (ORCID: https://orcid.org/0000-0003-3624-4501)
- Marcelo Calderón (ORCID: https://orcid.org/0000-0002-2734-9742)
- Aitor Díaz (ORCID: https://orcid.org/0000-0003-3338-9502)
- Mikel Azkargorta (ORCID: https://orcid.org/0000-0001-9115-3202)
- Juliana De Souza
- Ayla Basasoro
- Marta Rezola
Institutions
- Ikerbasque (ES)
- University of the Basque Country (ES)
- Centro Científico Tecnológico - Santa Fe (AR)
- Polymat (ES)
- Biogipuzkoa Health Research Institute (ES)
- CIC bioGUNE (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Hospital de Cruces (ES)
- Centre for Electrochemical Technologies (ES)
- Donostiako Unibertsitate Ospitalea (ES)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3389/fmed.2025.1498319
- Citations
- 2
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- Euskal Herriko Unibertsitatea
- Ikerbasque, Basque Foundation for Science