Dietary Pediococcus acidilactici improves the intestinal functions by regulating the expression of intestinal inflammatory genes and intestinal microbiota in aged laying hens at 80–91 weeks of age
Additionally, cecal metabolomic analysis indicated that following the addition of PA, the pathways enriched with differential metabolites were primarily related to arginine and proline metabolism. Therefore, PA has the potential to improve intestinal morphology and flora, mitigate intestinal inflammatory factors, and strengthen intestinal barrier function. These benefits are attributed to the modulation of arginine and proline metabolic pathways, with optimal effects observed at an addition of 50 mg/kg.
Authors
- Keying Zhang (ORCID: https://orcid.org/0000-0002-2909-3357)
- Airong Dong
- Yadong Mu (ORCID: https://orcid.org/0000-0001-7304-3069)
- Qiufeng Zeng
- Y. Liu (ORCID: https://orcid.org/0009-0000-2326-1113)
- Jianping Wang (ORCID: https://orcid.org/0000-0002-7141-3473)
- Shiping Bai (ORCID: https://orcid.org/0000-0002-5775-1900)
- Xuemei Ding (ORCID: https://orcid.org/0000-0003-4298-4493)
- Shanshan Li (ORCID: https://orcid.org/0000-0002-4182-0078)
- Huanwei Peng (ORCID: https://orcid.org/0000-0002-5383-9075)
- Yue Xuan
Institutions
- Sichuan Agricultural University (CN)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3389/fmicb.2025.1530319
- Citations
- 5
- Primary Topic
- Animal Nutrition and Physiology
- Type
- article
- Field-Weighted Citation Impact
- 5.97
Funders
- Natural Science Foundation of Sichuan Province