Multi-omics integration analysis of the amino-acid metabolism-related genes identifies putatively causal variants of ACCS associated with hepatitis B virus-related hepatocellular carcinoma survival
This study identified rs2074038 as a novel functional SNP associated with poor HBV-HCC survival, likely mediated genetic regulation of ACCS expression. These findings suggest that ACCS is a potential therapeutic target and highlight the need for further validation in clinical settings.
Authors
- Qian Guo (ORCID: https://orcid.org/0000-0002-1211-6436)
- Zihan Zhou (ORCID: https://orcid.org/0000-0002-0285-702X)
- Qiuyan Mo
- Qiuping Wen
- Qiuling Lin (ORCID: https://orcid.org/0000-0002-3239-4345)
- Xiumei Liang
- Hongping Yu (ORCID: https://orcid.org/0000-0001-9668-5929)
- Yingchun Liu (ORCID: https://orcid.org/0000-0002-5371-1274)
- Ji Cao (ORCID: https://orcid.org/0000-0003-2813-6404)
- Xiaobing Yang
- Xiaoxia Wei (ORCID: https://orcid.org/0000-0002-7350-3464)
- Moqin Qiu (ORCID: https://orcid.org/0000-0002-9618-0768)
- Peiqin Chen (ORCID: https://orcid.org/0009-0003-4013-8194)
- Yanji Jiang
- S C Duan
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Fourth Affiliated Hospital of Guangxi Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1186/s12885-025-13604-3
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Natural Science Foundation of Guangxi Province
- Guangxi Medical University
- Youth Science Foundation of Guangxi Medical University
- Science Fund for Distinguished Young Scholars of Guangxi Province