Articular cartilage degeneration and aberrant osteocyte perilacunar/canalicular remodeling in subchondral bone of patients with developmental dysplasia of the hip
Our findings indicate that the abnormal osteocyte activity in subchondral bone might contribute to the deterioration of subchondral bone structure, which accelerates cartilage degeneration and DDH progression. Targeting subchondral bone remodeling could offer a promising therapeutic strategy for DDH.
Authors
- Guoming Xie (ORCID: https://orcid.org/0000-0002-7497-1964)
- Zhifeng Yu (ORCID: https://orcid.org/0000-0002-2224-8344)
- Jiren Yan
- Tianyou Kan
- Linyang Chu (ORCID: https://orcid.org/0000-0001-9585-2967)
- Zhichang Zhang (ORCID: https://orcid.org/0000-0002-9497-9293)
- Wenjing Yin (ORCID: https://orcid.org/0000-0003-1932-5561)
- Teng Ye (ORCID: https://orcid.org/0000-0001-5124-2665)
- Bizeng Zhao
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1186/s12891-025-08419-z
- Citations
- 2
- Primary Topic
- Hip disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China