Evaluation of <scp>GS</scp>‐omega/kappa‐Hxtx‐Hv1a and <scp><i>Bt</i></scp> toxins against <scp><i>Bt</i>‐resistant</scp> and ‐susceptible strains of <scp><i>Helicoverpa zea</i></scp> (Boddie) and <scp><i>Spodoptera frugiperda</i></scp> (J.E. Smith)
The study confirms that ω/κ-Hv1a activity against H. zea is significantly enhanced by a facilitator mechanism. Our results suggest Cry1Ac pore formation in the midgut membrane of Cry-resistant H. zea, enables the activity of ω/κ-Hv1a. Vip3Aa resistance in H. zea involves altered toxin-binding, consequently preventing pore formation and activity of ω/κ-Hv1a. Therefore, insecticides containing ω/κ-Hv1a may be an alternative for managing Cry-resistant H. zea in cotton and help delay the evolution of insect resistance. © 2025 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Authors
- Heba Abdelgaffar (ORCID: https://orcid.org/0000-0003-2547-8302)
- José C Santiago‐González (ORCID: https://orcid.org/0000-0003-3917-4772)
- Dawson Kerns (ORCID: https://orcid.org/0000-0002-8144-9023)
- Xiaocun Sun (ORCID: https://orcid.org/0000-0003-3053-1518)
- Juan Luis Jurat‐Fuentes (ORCID: https://orcid.org/0000-0002-8945-1814)
- Fei Yang (ORCID: https://orcid.org/0000-0001-5162-4575)
- Simeon Ross
- David L. Kerns (ORCID: https://orcid.org/0000-0002-2992-4851)
- Dayna Collett
Institutions
- University of Minnesota (US)
- Research Triangle Park Foundation (US)
- University of Tennessee at Knoxville (US)
- Texas A&M University (US)
- Amarillo College (US)
Publication Details
- Journal
- Pest Management Science
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1002/ps.8725
- Citations
- 1
- Primary Topic
- Insect Resistance and Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Institute of Food and Agriculture