Resveratrol affects proliferation, apoptosis and migration of fibroblast cells as well as inhibits COL1A1/2 and TGFB2/3 gene expression
Primary fibroblasts isolated from pterygium and skin pathological scar were identified by immunofluorescence staining. It was found by CCK8 and TUNEL that high-dose resveratrol, a Chinese medicine monomer, could inhibit proliferation, promote apoptosis and restrain migration. Explored by whole-transcriptome sequencing and LC-MS/MS, 1531 up-regulated mRNAs, 1022 down-regulated mRNAs, 79 up-regulated proteins and 84 down-regulated proteins were identified in resveratrol-treated pterygium fibroblasts. It was shown by KEGG, GO, PPI and the following bioinformatics analysis that resveratrol may affect proliferation, apoptosis and migration of fibroblast through TGFB2/3 and COL1A1/2.
Authors
- Jicun Ding (ORCID: https://orcid.org/0000-0001-7163-8296)
- Zhiming Tang (ORCID: https://orcid.org/0000-0002-3037-1000)
- Zhiqiang Guan (ORCID: https://orcid.org/0000-0001-5087-6439)
- Yiling Zhang (ORCID: https://orcid.org/0009-0003-2623-3232)
- Meili Li (ORCID: https://orcid.org/0000-0002-2725-3978)
- Kun Pang (ORCID: https://orcid.org/0000-0002-9063-8483)
- Lei Qiao (ORCID: https://orcid.org/0000-0003-2907-7629)
- Chaoju Gong (ORCID: https://orcid.org/0000-0002-8058-4194)
- Songtao Li
Institutions
- Jiangsu University (CN)
- Xuzhou Medical College (CN)
- Xuzhou Cancer Hospital (CN)
- Xuzhou Central Hospital (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
- Xuzhou No.1 People's Hospital (CN)
- Cixian People's Hospital (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1080/10286020.2025.2462610
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Postdoctoral Science Foundation
- Xuzhou Science and Technology Program