IDO1 modulates pain sensitivity and comorbid anxiety in chronic migraine through microglial activation and synaptic pruning
Our findings revealed that microglial IDO1 in the ACC drives pain sensitization and anxiety in chronic migraine, highlighting IDO1 as a potential therapeutic target for chronic migraine treatment.
Authors
- Wei Xie (ORCID: https://orcid.org/0000-0002-3844-3013)
- Yun-Yan Zhao
- Yifan Xiong (ORCID: https://orcid.org/0000-0002-1168-9179)
- Jiao Hu
- Wen-Juan Ji (ORCID: https://orcid.org/0000-0002-3767-0169)
- Weipeng Li (ORCID: https://orcid.org/0000-0001-6060-7232)
- Xiaohong Su (ORCID: https://orcid.org/0000-0002-3939-0291)
- Gui-Yu Liu
- Jun-Ming Zhu
- Yu Hong
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Guangzhou University (CN)
- Integrated Chinese Medicine (China) (HK)
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1186/s12974-025-03367-w
- Citations
- 13
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 19.13
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Basic and Applied Basic Research Foundation of Guangdong Province