Aging triggers mitochondrial, endoplasmic reticulum, and metabolic stress responses in the heart
These findings demonstrate that aging triggers mt, ER, and oxidative stress in the heart, which over time leads to the accumulation of oxidative damage, causing cellular impairment, highlighting these pathways as potential therapeutic targets for mitigating age-related cardiac dysfunction.
Authors
- Sakthijothi Muthu (ORCID: https://orcid.org/0000-0001-5684-0680)
- Sundararajan Venkatesh (ORCID: https://orcid.org/0000-0003-4195-7776)
- Carolyn K. Suzuki (ORCID: https://orcid.org/0000-0003-2187-7568)
- Edouard I. Azzam (ORCID: https://orcid.org/0000-0002-8968-1142)
- Jayapalraja Thilagavathi
- Zinnia Tran
- Tanvi Bolarum
Institutions
- Rutgers, The State University of New Jersey (US)
- West Virginia University (US)
- Rutgers New Jersey Medical School (US)
Publication Details
- Journal
- The Journal of Cardiovascular Aging
- Published
- 2025-02-18
- DOI
- https://doi.org/10.20517/jca.2024.17
- Citations
- 6
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Aeronautics and Space Administration
- American Heart Association
- Nuclear Safety and Security Commission