Integration of single-cell and spatial transcriptomics reveals fibroblast subtypes in hepatocellular carcinoma: spatial distribution, differentiation trajectories, and therapeutic potential
We characterized three fibroblast subpopulations in HCC and revealed their distinct spatial distributions within the tumor. VEGFA + CAFs, which was induced by hypoxic TME, were associated with poorer prognosis, as they promote tumor angiogenesis through cellular communication with CapECs. Our findings provide novel insights and pave the way for individualized therapy in HCC patients.
Authors
- Ping Liang (ORCID: https://orcid.org/0000-0001-8933-6392)
- Jie Yu (ORCID: https://orcid.org/0000-0002-1168-8766)
- Guoping Dong (ORCID: https://orcid.org/0000-0002-8498-1226)
- Yue Liu (ORCID: https://orcid.org/0000-0002-7136-1298)
Institutions
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1186/s12967-025-06192-0
- Citations
- 21
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 16.93
Funders
- National Natural Science Foundation of China