Sex differences in the association of Alzheimer’s disease biomarkers and cognition in a multicenter memory clinic study
Women showed higher tau load and stronger association between amyloid and tau than men. In individuals with high tau burden, men exhibited greater neurodegeneration and cognitive impairment than women. These findings support that sex differences may impact tau deposition through an upstream interplay with amyloid, leading to downstream effects on neurodegeneration and cognitive outcomes.
Authors
- Linjing Mu (ORCID: https://orcid.org/0000-0001-5354-1546)
- Alessandra Griffa (ORCID: https://orcid.org/0000-0003-1923-1653)
- John Olivier Prior (ORCID: https://orcid.org/0000-0003-1429-1374)
- Cecilia Boccalini (ORCID: https://orcid.org/0000-0002-3518-436X)
- Nathalie Testart Dardel (ORCID: https://orcid.org/0000-0002-1556-5771)
- Max Scheffler
- Valentina Garibotto (ORCID: https://orcid.org/0000-0003-2422-698X)
- Gilles Allali (ORCID: https://orcid.org/0000-0002-4455-6719)
- Débora Elisa Peretti (ORCID: https://orcid.org/0000-0002-3033-8817)
- Kaj Blennow
- Nicholas J. Ashton
- Giovanni B. Frisoni (ORCID: https://orcid.org/0000-0001-7075-7082)
- Henrik Zetterberg
Institutions
- University of Geneva (CH)
- University of Science and Technology of China (CN)
- University of Wisconsin–Madison (US)
- King's College London (GB)
- Hong Kong University of Science and Technology (HK)
- Stavanger University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Centre for Mental Health (GB)
- ETH Zurich (CH)
- Sorbonne Université (FR)
- University Hospital of Geneva (CH)
- Institut de Myologie (FR)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Centre d'Imagerie BioMedicale (CH)
- MRC Prion Unit (GB)
- University College London (GB)
- École Polytechnique Fédérale de Lausanne (CH)
- University of Gothenburg (SE)
- University of Lausanne (CH)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1186/s13195-025-01684-z
- Citations
- 29
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 42.67
Funders
- Eidgenössische Technische Hochschule Zürich
- Université de Genève
- Avid Radiopharmaceuticals