GCC and RNFL Changes Following Topical Therapy in Primary Open-Angle Glaucoma

Background and Objectives: Gradual loss of retinal ganglion cells and their axons, primarily in the retinal nerve fibre layer (RNFL), is the cause of glaucoma, a progressive optic neuropathy that is one of the leading causes of irreversible blindness globally.This study was conducted to ascertain Immediate change In Optic Nerve Head Stereometric Parameters In Primary Open-angle Glaucoma After Topical Medical Therapy.METHODOLOGY: In this study, 120 patients diagnosed with primary open angle glaucoma were enrolled.These subjects had no other ocular or systemic illness.Patients with primary open glaucoma confirmed by glaucoma specialist were undergone for GCC (ganglion cell complex), RNFL (retinal nerve fibre layer), FLV (focal loss volume) and GLV (gross loss volume) measurement by OCT (RTVue-100;Optovue, version 6.1..0.21).After seeking glaucoma topical medical therapy by glaucoma specialist patients were revisited after one month.OCT was performed again to measure the GCC and RNFL, GLV and FLV again to observe the change in these values.The analysis of data was done by using SPSS version 22. Quantitative data was presented in terms of mean S.D and S.E. and qualitative data was presented in form of Pie chart.Normality assumption was checked by One Sample Kolmogorov-Smirnov test and all the variables were considered in normal distribution having p value > 0.05.RESULTS: Out of 120 patients having primary open glaucoma.53% were male and 46% were females.Mean age of patients was 52 years.Mean GCC was found to be improved with a difference of 0.731.02,p > 0.05 before and after the treatment.Average RNFL before the treatment was 82.98 9.93 and after was 83.61 10.0 with a difference of 0.63 0.03 p <0.05.FLV before the treatment was 4.19 3.68 and after was 3.51 2.82 with a mean difference of 0.68 0.86 p > 0.05.average GLV before the treatment was 14.09 6.92 and after was 15.08 6.89 with a mean difference of 0.9 0.03, p >0.05.CONCLUSION: Following topical medicinal therapy, immediate changes in ONH stereometric parameters in POAG patients provide important information about the early response to treatment and may be indicative of long-term outcomes.