Apelin-13 attenuates optic nerve damage in glaucomatous mice by regulating glucose metabolism
These findings imply that altered glucose metabolism in the visual center may be an early sign of optic nerve damage in patients with glaucoma. Apelin-13 may rely on the PI3K/Akt signaling pathway to regulate the redistribution of energy metabolism in the retina and visual centers, thereby mitigating oxidative stress and safeguarding neuronal cells.
Authors
- Jiajun Zhao (ORCID: https://orcid.org/0000-0003-3267-9292)
- Ling Yu (ORCID: https://orcid.org/0000-0001-6395-6630)
- Zhen Jiang (ORCID: https://orcid.org/0000-0001-6520-2226)
- Caifeng Lei
- Kaihui Cheng (ORCID: https://orcid.org/0000-0002-4792-0707)
- Ya Zhang (ORCID: https://orcid.org/0000-0002-1746-3437)
- Jian Zhou (ORCID: https://orcid.org/0000-0002-2118-1117)
Institutions
- Army Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Daping Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1186/s12967-025-06212-z
- Citations
- 5
- Primary Topic
- Apelin-related biomedical research
- Type
- article
- Field-Weighted Citation Impact
- 6.97
Funders
- National Natural Science Foundation of China
- Southwest Medical University
- Affiliated Hospital of Southwest Medical University